MME

GENE INFORMATION

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Gene name

MME (HGNC Symbol)

Synonyms

CALLA, CD10, NEP

Description

membrane metallo-endopeptidase (HGNC Symbol)

Entrez gene summary

This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing. [provided by RefSeq, Jul 2008]

Chromosome

3 (Chromosome progress)

Cytoband

q25.2

Chromosome location (bp)

154741913 - 154901497

Ensembl

ENSG00000196549 (version 73.37)

Entrez gene

4311

UniProt

P08473 (UniProt - Evidence at protein level)

neXtProt

NX_P08473

Antibodypedia

MME antibodies
 

PROTEIN VIEW

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 « 
 
MME-001
 
MME-003
 
MME-004
 
MME-005
 
MME-006
 
MME-007
 
MME-008
 
MME-009
 
MME-010
 
MME-011
 
MME-012
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MME-001 ENSP00000418525
ENST00000460393
P08473
Show all »
Show » Show » 750 85.5 No 0
MME-003 ENSP00000372450
ENST00000382989
Q3KQS6
Show all »
Show » Show » 80 8.9 No 1
MME-004 ENSP00000419653
ENST00000462745
P08473
Show all »
Show » Show » 750 85.5 No 0
MME-005 ENSP00000417079
ENST00000493237
P08473
Show all »
Show » Show » 750 85.5 No 0
MME-006 ENSP00000353679
ENST00000360490
P08473
Show all »
Show » Show » 750 85.5 No 0
MME-007 ENSP00000420389
ENST00000492661
P08473
Show all »
Show » Show » 750 85.5 No 0
MME-008 ENSP00000420101
ENST00000481828
C9JR96
Show all »
Show » Show » 233 26.2 No 0
MME-009 ENSP00000418791
ENST00000491026
C9IYX7
Show all »
Show » Show » 119 13.4 No 0
MME-010 ENSP00000420542
ENST00000473730
C9JDZ3
Show all »
Show » Show » 93 10.4 No 0
MME-011 ENSP00000418238
ENST00000497890
15 1.7 No 0
MME-012 ENSP00000417595
ENST00000462837
C9J9X7
Show all »
Show » Show » 161 18 No 0