MMP1

GENE INFORMATION

? »

Gene name

MMP1 (HGNC Symbol)

Synonyms

CLG

Description

Matrix metallopeptidase 1 (interstitial collagenase) (HGNC Symbol)

Entrez gene summary

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes a secreted enzyme which breaks down the interstitial collagens, types I, II, and III. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]

Chromosome

11

Cytoband

q22.2

Chromosome location (bp)

102660651 - 102668891

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000196611 (version 75.37)

Entrez gene

4312

UniProt

P03956 (UniProt - Evidence at protein level)

neXtProt

NX_P03956

Antibodypedia

MMP1 antibodies
 

PROTEIN VIEW

? »
 
 
 
MMP1-001
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MMP1-001 ENSP00000322788
ENST00000315274
P03956
Show all »
Show » Show » 469 54 Yes 0