HSH2D

GENERAL INFORMATION

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Gene name

HSH2D

Gene description

Hematopoietic SH2 domain containing

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Tissue enhanced (small intestine, spleen)

Protein evidence

Evidence at protein level

Protein localization

Most of the normal cells showed weak to moderate cytoplasmic positivity with additional luminal membranous staining. Purkinje cells of cerebellum and subsets of skeletal muscle cells were strongly stained. Endometrial glands, breast and lymphoid tissues were negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA036616
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Cerebellum

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (small intestine, spleen)

Organ

Expression



GENE INFORMATION

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Gene name

HSH2D (HGNC Symbol)

Synonyms

ALX, FLJ14886, HSH2

Description

Hematopoietic SH2 domain containing (HGNC Symbol)

Entrez gene summary

T-cell activation requires 2 signals: recognition of antigen by the T-cell receptor (see TCR; MIM 186880) and a costimulatory signal provided primarily by CD28 (MIM 186760) in naive T cells. HSH2 is a target of both of these signaling pathways (Greene et al., 2003 [PubMed 12960172]).[supplied by OMIM, Mar 2008]

Chromosome

19

Cytoband

p13.11

Chromosome location (bp)

16134028 - 16158575

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000196684 (version 78.38)

Entrez gene

84941

UniProt

Q96JZ2 (UniProt - Evidence at protein level)

neXtProt

NX_Q96JZ2

Antibodypedia

HSH2D antibodies


PROTEIN BROWSER

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ENST00000593031
 
ENST00000613986
 
ENST00000616645
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HSH2D-001 ENSP00000483354
ENST00000613986
Q96JZ2
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Show » Show » 352 39 No 0
HSH2D-007 ENSP00000467189
ENST00000593031
K7EP18
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Show » 173 19.2 No 0
HSH2D-009 ENSP00000482604
ENST00000616645
Q96JZ2
Show all »
Show » Show » 352 39 No 0