TRPV1

GENE INFORMATION

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Gene name

TRPV1 (HGNC Symbol)

Synonyms

VR1

Description

transient receptor potential cation channel, subfamily V, member 1 (HGNC Symbol)

Entrez gene summary

Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene. [provided by RefSeq, Jul 2008]

Chromosome

17 (Chromosome progress)

Cytoband

p13.2

Chromosome location (bp)

3468738 - 3500392

Ensembl

ENSG00000196689 (version 73.37)

Entrez gene

7442

UniProt

Q8NER1 (UniProt - Evidence at protein level)

neXtProt

NX_Q8NER1

Antibodypedia

TRPV1 antibodies
 

PROTEIN VIEW

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TRPV1-001
 
TRPV1-002
 
TRPV1-003
 
TRPV1-004
 
TRPV1-005
 
TRPV1-006
 
TRPV1-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TRPV1-001 ENSP00000461007
ENST00000571088
Q8NER1
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Show » Show » 839 95 No 6
TRPV1-002 ENSP00000382661
ENST00000399759
Q8NER1
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Show » Show » 839 95 No 6
TRPV1-003 ENSP00000382659
ENST00000399756
Q8NER1
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Show » Show » 839 95 No 6
TRPV1-004 ENSP00000459042
ENST00000576351
I3L1R6
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Show » Show » 829 93.9 No 6
TRPV1-005 ENSP00000409627
ENST00000425167
E7EQ78
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Show » Show » 850 96.1 No 6
TRPV1-006 ENSP00000311692
ENST00000310522
E7ESJ2
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Show » Show » 779 88.1 No 6
TRPV1-201 ENSP00000174621
ENST00000174621
J3QK85
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Show » Show » 837 94.2 No 6