The gene information section lists the gene name (HUGO Gene Nomenclature Committee (HGNC) name if available), any approved gene synonyms, Ensembl gene description, and the Entrez gene summary from the National Center for Biotechnology Information.
The chromosomal and cytoband location of the gene according to Ensembl is reported together with the Ensembl gene identifier and Ensembl database version. The Entrez gene identifier for the gene is also given. If any of the protein products of the gene is linked to a UniProt KB/SWISS-PROT entry, links to the UniProt and the neXtProt databases for these proteins are displayed.
Gene name
HLA-DQA1 (HGNC Symbol)
Synonyms
CELIAC1, HLA-DQA
Description
major histocompatibility complex, class II, DQ alpha 1 (HGNC Symbol)
Entrez gene summary
HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. [provided by RefSeq, Jul 2008]
The protein view displays protein features. The tabs at the top of the protein view section can be used to switch between the different splice variants encoded by this gene. The mouse over function displays additional data for the features in the protein view.
At the top of the protein view, the maximum percent sequence identity of the protein to all other proteins from other human genes is shown, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50) (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0 and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Common (purple) and unique (grey) regions between alternative processed transcripts from the same gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
The protein information section displays the alternative protein-coding transcripts (splice variants) encoded by this gene, according to the Ensembl database.
The ENSP identifier links to the Ensembl website for that protein, and the ENST identifier links to the Ensembl website for that transcript. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes to which this protein has been assigned are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column.
The length of the protein (amino acid residues) (according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0 and Phobius and predicted transmembrane region(s) (according to MDM) are also reported.
P01909 [Direct mapping] HLA class II histocompatibility antigen, DQ alpha 1 chain Q30065 [Target identity:89%; Query identity:100%] MHC class II HLA-DQ-alpha chain Q30066 [Target identity:89%; Query identity:100%] MHC class II HLA-DQ-alpha chain Q67AH6 [Target identity:89%; Query identity:100%] MHC class II antigen Q67AH7 [Target identity:89%; Query identity:100%] MHC class II antigen Q67AH8 [Target identity:89%; Query identity:100%] MHC class II antigen Q67AH9 [Target identity:89%; Query identity:100%] MHC class II antigen Q67AI0 [Target identity:89%; Query identity:100%] MHC class II antigen Q67AI1 [Target identity:89%; Query identity:100%] MHC class II antigen Q67AI2 [Target identity:89%; Query identity:100%] MHC class II antigen O19703 [Target identity:10%; Query identity:100%] MHC class II HLA-DQ-alpha-1 Q67A92 [Target identity:10%; Query identity:100%] MHC class II antigen Q67A93 [Target identity:10%; Query identity:100%] MHC class II antigen Q67AA5 [Target identity:10%; Query identity:100%] MHC class II antigen Q67AA6 [Target identity:10%; Query identity:100%] MHC class II antigen Q67AA7 [Target identity:10%; Query identity:100%] MHC class II antigen Q67AB5 [Target identity:10%; Query identity:100%] MHC class II antigen Q67AB6 [Target identity:10%; Query identity:100%] MHC class II antigen Q67AB7 [Target identity:10%; Query identity:100%] MHC class II antigen Q67AB8 [Target identity:10%; Query identity:100%] MHC class II antigen Q67AB9 [Target identity:10%; Query identity:100%] MHC class II antigen Q67AC0 [Target identity:10%; Query identity:100%] MHC class II antigen Q67AC1 [Target identity:10%; Query identity:100%] MHC class II antigen Q67AC2 [Target identity:10%; Query identity:100%] MHC class II antigen Q67AC3 [Target identity:10%; Query identity:100%] MHC class II antigen Q67AC4 [Target identity:10%; Query identity:100%] MHC class II antigen F6UB03 [Target identity:9%; Query identity:100%] HLA class II histocompatibility antigen, DQ alpha 1 chain
E9PI37 [Target identity:100%; Query identity:100%] HLA class II histocompatibility antigen, DQ alpha 1 chain O19703 [Target identity:50%; Query identity:100%] MHC class II HLA-DQ-alpha-1 Q67A92 [Target identity:50%; Query identity:100%] MHC class II antigen Q67A93 [Target identity:50%; Query identity:100%] MHC class II antigen Q67AA5 [Target identity:50%; Query identity:100%] MHC class II antigen Q67AA6 [Target identity:50%; Query identity:100%] MHC class II antigen Q67AA7 [Target identity:50%; Query identity:100%] MHC class II antigen Q67AB5 [Target identity:50%; Query identity:100%] MHC class II antigen Q67AB6 [Target identity:50%; Query identity:100%] MHC class II antigen Q67AB7 [Target identity:50%; Query identity:100%] MHC class II antigen Q67AB8 [Target identity:50%; Query identity:100%] MHC class II antigen Q67AB9 [Target identity:50%; Query identity:100%] MHC class II antigen Q67AC0 [Target identity:50%; Query identity:100%] MHC class II antigen Q67AC1 [Target identity:50%; Query identity:100%] MHC class II antigen Q67AC2 [Target identity:50%; Query identity:100%] MHC class II antigen Q67AC3 [Target identity:50%; Query identity:100%] MHC class II antigen Q67AC4 [Target identity:50%; Query identity:100%] MHC class II antigen F6UB03 [Target identity:45%; Query identity:100%] HLA class II histocompatibility antigen, DQ alpha 1 chain
P01909 [Direct mapping] HLA class II histocompatibility antigen, DQ alpha 1 chain Q30065 [Target identity:89%; Query identity:100%] MHC class II HLA-DQ-alpha chain Q30066 [Target identity:89%; Query identity:100%] MHC class II HLA-DQ-alpha chain Q67AH6 [Target identity:89%; Query identity:100%] MHC class II antigen Q67AH7 [Target identity:89%; Query identity:100%] MHC class II antigen Q67AH8 [Target identity:89%; Query identity:100%] MHC class II antigen Q67AH9 [Target identity:89%; Query identity:100%] MHC class II antigen Q67AI0 [Target identity:89%; Query identity:100%] MHC class II antigen Q67AI1 [Target identity:89%; Query identity:100%] MHC class II antigen Q67AI2 [Target identity:89%; Query identity:100%] MHC class II antigen O19703 [Target identity:10%; Query identity:100%] MHC class II HLA-DQ-alpha-1 Q67A92 [Target identity:10%; Query identity:100%] MHC class II antigen Q67A93 [Target identity:10%; Query identity:100%] MHC class II antigen Q67AA5 [Target identity:10%; Query identity:100%] MHC class II antigen Q67AA6 [Target identity:10%; Query identity:100%] MHC class II antigen Q67AA7 [Target identity:10%; Query identity:100%] MHC class II antigen Q67AB5 [Target identity:10%; Query identity:100%] MHC class II antigen Q67AB6 [Target identity:10%; Query identity:100%] MHC class II antigen Q67AB7 [Target identity:10%; Query identity:100%] MHC class II antigen Q67AB8 [Target identity:10%; Query identity:100%] MHC class II antigen Q67AB9 [Target identity:10%; Query identity:100%] MHC class II antigen Q67AC0 [Target identity:10%; Query identity:100%] MHC class II antigen Q67AC1 [Target identity:10%; Query identity:100%] MHC class II antigen Q67AC2 [Target identity:10%; Query identity:100%] MHC class II antigen Q67AC3 [Target identity:10%; Query identity:100%] MHC class II antigen Q67AC4 [Target identity:10%; Query identity:100%] MHC class II antigen F6UB03 [Target identity:9%; Query identity:100%] HLA class II histocompatibility antigen, DQ alpha 1 chain
P01909 [Direct mapping] HLA class II histocompatibility antigen, DQ alpha 1 chain Q30065 [Target identity:89%; Query identity:100%] MHC class II HLA-DQ-alpha chain Q30066 [Target identity:89%; Query identity:100%] MHC class II HLA-DQ-alpha chain Q67AH6 [Target identity:89%; Query identity:100%] MHC class II antigen Q67AH7 [Target identity:89%; Query identity:100%] MHC class II antigen Q67AH8 [Target identity:89%; Query identity:100%] MHC class II antigen Q67AH9 [Target identity:89%; Query identity:100%] MHC class II antigen Q67AI0 [Target identity:89%; Query identity:100%] MHC class II antigen Q67AI1 [Target identity:89%; Query identity:100%] MHC class II antigen Q67AI2 [Target identity:89%; Query identity:100%] MHC class II antigen O19703 [Target identity:10%; Query identity:100%] MHC class II HLA-DQ-alpha-1 Q67A92 [Target identity:10%; Query identity:100%] MHC class II antigen Q67A93 [Target identity:10%; Query identity:100%] MHC class II antigen Q67AA5 [Target identity:10%; Query identity:100%] MHC class II antigen Q67AA6 [Target identity:10%; Query identity:100%] MHC class II antigen Q67AA7 [Target identity:10%; Query identity:100%] MHC class II antigen Q67AB5 [Target identity:10%; Query identity:100%] MHC class II antigen Q67AB6 [Target identity:10%; Query identity:100%] MHC class II antigen Q67AB7 [Target identity:10%; Query identity:100%] MHC class II antigen Q67AB8 [Target identity:10%; Query identity:100%] MHC class II antigen Q67AB9 [Target identity:10%; Query identity:100%] MHC class II antigen Q67AC0 [Target identity:10%; Query identity:100%] MHC class II antigen Q67AC1 [Target identity:10%; Query identity:100%] MHC class II antigen Q67AC2 [Target identity:10%; Query identity:100%] MHC class II antigen Q67AC3 [Target identity:10%; Query identity:100%] MHC class II antigen Q67AC4 [Target identity:10%; Query identity:100%] MHC class II antigen F6UB03 [Target identity:9%; Query identity:100%] HLA class II histocompatibility antigen, DQ alpha 1 chain
E9PMV2 [Target identity:100%; Query identity:100%] HLA class II histocompatibility antigen, DQ alpha 1 chain O19703 [Target identity:12%; Query identity:100%] MHC class II HLA-DQ-alpha-1 Q67A92 [Target identity:12%; Query identity:100%] MHC class II antigen Q67A93 [Target identity:12%; Query identity:100%] MHC class II antigen Q67AA5 [Target identity:12%; Query identity:100%] MHC class II antigen Q67AA6 [Target identity:12%; Query identity:100%] MHC class II antigen Q67AA7 [Target identity:12%; Query identity:100%] MHC class II antigen Q67AB5 [Target identity:12%; Query identity:100%] MHC class II antigen Q67AB6 [Target identity:12%; Query identity:100%] MHC class II antigen Q67AB7 [Target identity:12%; Query identity:100%] MHC class II antigen Q67AB8 [Target identity:12%; Query identity:100%] MHC class II antigen Q67AB9 [Target identity:12%; Query identity:100%] MHC class II antigen Q67AC0 [Target identity:12%; Query identity:100%] MHC class II antigen Q67AC1 [Target identity:12%; Query identity:100%] MHC class II antigen Q67AC2 [Target identity:12%; Query identity:100%] MHC class II antigen Q67AC3 [Target identity:12%; Query identity:100%] MHC class II antigen Q67AC4 [Target identity:12%; Query identity:100%] MHC class II antigen F6UB03 [Target identity:11%; Query identity:100%] HLA class II histocompatibility antigen, DQ alpha 1 chain
GO:0002504 [antigen processing and presentation of peptide or polysaccharide antigen via MHC class II] GO:0006955 [immune response] GO:0016021 [integral to membrane] GO:0042613 [MHC class II protein complex]
P01909 [Direct mapping] HLA class II histocompatibility antigen, DQ alpha 1 chain Q30065 [Target identity:89%; Query identity:100%] MHC class II HLA-DQ-alpha chain Q30066 [Target identity:89%; Query identity:100%] MHC class II HLA-DQ-alpha chain Q67AH6 [Target identity:89%; Query identity:100%] MHC class II antigen Q67AH7 [Target identity:89%; Query identity:100%] MHC class II antigen Q67AH8 [Target identity:89%; Query identity:100%] MHC class II antigen Q67AH9 [Target identity:89%; Query identity:100%] MHC class II antigen Q67AI0 [Target identity:89%; Query identity:100%] MHC class II antigen Q67AI1 [Target identity:89%; Query identity:100%] MHC class II antigen Q67AI2 [Target identity:89%; Query identity:100%] MHC class II antigen O19703 [Target identity:10%; Query identity:100%] MHC class II HLA-DQ-alpha-1 Q67A92 [Target identity:10%; Query identity:100%] MHC class II antigen Q67A93 [Target identity:10%; Query identity:100%] MHC class II antigen Q67AA5 [Target identity:10%; Query identity:100%] MHC class II antigen Q67AA6 [Target identity:10%; Query identity:100%] MHC class II antigen Q67AA7 [Target identity:10%; Query identity:100%] MHC class II antigen Q67AB5 [Target identity:10%; Query identity:100%] MHC class II antigen Q67AB6 [Target identity:10%; Query identity:100%] MHC class II antigen Q67AB7 [Target identity:10%; Query identity:100%] MHC class II antigen Q67AB8 [Target identity:10%; Query identity:100%] MHC class II antigen Q67AB9 [Target identity:10%; Query identity:100%] MHC class II antigen Q67AC0 [Target identity:10%; Query identity:100%] MHC class II antigen Q67AC1 [Target identity:10%; Query identity:100%] MHC class II antigen Q67AC2 [Target identity:10%; Query identity:100%] MHC class II antigen Q67AC3 [Target identity:10%; Query identity:100%] MHC class II antigen Q67AC4 [Target identity:10%; Query identity:100%] MHC class II antigen F6UB03 [Target identity:9%; Query identity:100%] HLA class II histocompatibility antigen, DQ alpha 1 chain
