HLA-DQA1

GENE INFORMATION

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Gene name

HLA-DQA1 (HGNC Symbol)

Synonyms

CELIAC1, HLA-DQA

Description

major histocompatibility complex, class II, DQ alpha 1 (HGNC Symbol)

Entrez gene summary

HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. [provided by RefSeq, Jul 2008]

Chromosome

6 (Chromosome progress)

Cytoband

p21.32

Chromosome location (bp)

32595956 - 32614839

Ensembl

ENSG00000196735 (version 73.37)

Entrez gene

3117

UniProt

P01909 (UniProt - Evidence at protein level)

neXtProt

NX_P01909

Antibodypedia

HLA-DQA1 antibodies
 

PROTEIN VIEW

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HLA-DQA1-001
 
HLA-DQA1-002
 
HLA-DQA1-004
 
HLA-DQA1-007
 
HLA-DQA1-009
 
HLA-DQA1-010
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HLA-DQA1-001 ENSP00000339398
ENST00000343139
P01909
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Show » Show » 255 28 Yes 1
HLA-DQA1-002 ENSP00000436546
ENST00000482745
E9PI37
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53 5.6 Yes 0
HLA-DQA1-004 ENSP00000378767
ENST00000395363
P01909
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Show » Show » 255 28 Yes 1
HLA-DQA1-007 ENSP00000437302
ENST00000496318
E9PMV2
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Show » Show » 214 23.7 Yes 0
HLA-DQA1-009 ENSP00000364087
ENST00000374949
P01909
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Show » Show » 255 28 Yes 1
HLA-DQA1-010 ENSP00000405797
ENST00000422863
F6UB03
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24 2.4 Yes 0