ARHGEF12

GENE INFORMATION

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Gene name

ARHGEF12 (HGNC Symbol)

Synonyms

KIAA0382, LARG

Description

Rho guanine nucleotide exchange factor (GEF) 12 (HGNC Symbol)

Entrez gene summary

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli working through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein has been observed to form a myeloid/lymphoid fusion partner in acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

Chromosome

11 (Chromosome progress)

Cytoband

q23.3

Chromosome location (bp)

120207787 - 120360645

Ensembl

ENSG00000196914 (version 73.37)

Entrez gene

23365

UniProt

Q9NZN5 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NZN5

Antibodypedia

ARHGEF12 antibodies
 

PROTEIN VIEW

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ARHGEF12-001
 
ARHGEF12-003
 
ARHGEF12-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ARHGEF12-001 ENSP00000380942
ENST00000397843
Q9NZN5
Show all »
Show » Show » 1544 173.2 No 0
ARHGEF12-003 ENSP00000432984
ENST00000532993
E9PMR6
Show all »
Show » Show » 1441 161.9 No 0
ARHGEF12-201 ENSP00000349056
ENST00000356641
Q9NZN5
Show all »
Show » Show » 1525 171.1 No 0