FLNA

GENE INFORMATION

? »

Gene name

FLNA (HGNC Symbol)

Synonyms

ABP-280, FLN, FLN1, OPD1, OPD2

Description

filamin A, alpha (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]

Chromosome

X (Chromosome progress)

Cytoband

q28

Chromosome location (bp)

153576892 - 153603006

Ensembl

ENSG00000196924 (version 73.37)

Entrez gene

2316

UniProt

P21333 (UniProt - Evidence at protein level)

neXtProt

NX_P21333

Antibodypedia

FLNA antibodies
 

PROTEIN VIEW

? »
 
 
 
FLNA-001
 
FLNA-002
 
FLNA-010
 
FLNA-015
 
FLNA-016
 
FLNA-019
 
FLNA-021
 
FLNA-201
 
FLNA-202
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FLNA-001 ENSP00000353467
ENST00000360319
P21333
Show all »
Show » Show » 2639 280 No 0
FLNA-002 ENSP00000358866
ENST00000369850
P21333
Show all »
Show » Show » 2647 280.7 No 0
FLNA-010 ENSP00000358863
ENST00000344736
Q5HY54
Show all »
Show » Show » 2607 276.5 No 0
FLNA-015 ENSP00000398215
ENST00000438732
Show » 232 25 No 0
FLNA-016 ENSP00000397824
ENST00000444578
H0Y5C6
Show all »
Show » 281 29.9 No 0
FLNA-019 ENSP00000405458
ENST00000415241
90 9.7 No 0
FLNA-021 ENSP00000408921
ENST00000420627
F8WE98
Show all »
Show » Show » 604 66.6 No 0
FLNA-201 ENSP00000358872
ENST00000369856
E9PHF0
Show all »
Show » 780 82.5 No 0
FLNA-202 ENSP00000416926
ENST00000422373
P21333
Show all »
Show » Show » 2639 280 No 0