CASP4

GENE INFORMATION

? »

Gene name

CASP4 (HGNC Symbol)

Synonyms

ICE(rel)II, ICH-2, TX

Description

caspase 4, apoptosis-related cysteine peptidase (HGNC Symbol)

Entrez gene summary

This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Chromosome

11 (Chromosome progress)

Cytoband

q22.3

Chromosome location (bp)

104813593 - 104840163

Ensembl

ENSG00000196954 (version 73.37)

Entrez gene

837

UniProt

P49662 (UniProt - Evidence at protein level)

neXtProt

NX_P49662

Antibodypedia

CASP4 antibodies
 

PROTEIN VIEW

? »
 
 
 
CASP4-001
 
CASP4-004
 
CASP4-007
 
CASP4-013
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CASP4-001 ENSP00000388566
ENST00000444739
P49662
Show all »
Show » Show » 377 43.3 No 0
CASP4-004 ENSP00000376857
ENST00000393150
P49662
Show all »
Show » Show » 321 36.7 No 0
CASP4-007 ENSP00000401673
ENST00000417440
E9PMT1
Show all »
Show » 147 17.1 No 0
CASP4-013 ENSP00000432879
ENST00000533252
Show » 72 8.1 No 0