The cancer tissue page shows antibody staining in 20 different cancers. The overall cancer tissue staining statistics shows the fraction of patient samples with strong, moderate, weak or no staining (as described by the color-coding scale in the box to the right), using all the available antibodies to the protein targets encoded by this gene. The assay and annotation is described here.
The cancers can be ordered histologically or alphabetically.
For each cancer, the staining for each available antibody is reported as the fraction of samples with strong, moderate, weak or no staining (as described by the color-coding scale in the box to the right). The lenght of the bar represents the number of patient samples analysed (max=12 patients). By clicking on a cancer tissue, the detailed staining data for that cancer is available, including annotated images.
At the bottom of this page, a summary for the cancer staining for each antibody is given, together with the immunohistochemistry validation score for that antibody.
Most malignancies showed strong nuclear staining. Malignant lymphomas, cervical squamous cell carcinomas and testicular tumors as well as several colorectal cancers were negative.
Moderate to strong positivity was displayed in non-Hodgkin's lymphomas while breast, testicular, liver and thyroid cancers were moderately positive in a majority of cases. Tumor cells were in general weakly stained or negative.
Cancer tissues showed moderate to strong nuclear immunoreactivity, along with occasional cytoplasmic and membranous staining. Several cases of duct carcinomas of breast, colorectal and pancreatic cancers displayed strong nuclear, cytoplasmic and membranous positivity.
Validation
The multi-targeting antibody yielding a staining pattern partly consistent with characterization data for at least one of the genes whereas any of the other genes has no available gene/protein characterization data or is contradicted by gene/protein chara
The multi-targeting antibody yielding a staining pattern partly consistent with limited gene/protein characterization data or there is no available gene/protein characterization data for all or at least one of the genes
The multi-targeting antibody yielding a staining pattern consistent with gene/protein characterization data for at least one of the genes whereas any of the other genes has no available gene/protein characterization data or is contradicted by gene/protein
