IGF2R

GENE INFORMATION

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Gene name

IGF2R (HGNC Symbol)

Synonyms

CD222, CIMPR, M6P-R, MPR1, MPRI

Description

insulin-like growth factor 2 receptor (HGNC Symbol)

Entrez gene summary

This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate, although the binding sites for either are located on different segments of the receptor. This receptor functions in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. While the related mouse gene shows exclusive expression from the maternal allele, imprinting of the human gene appears to be polymorphic, with only a minority of individuals showing expression from the maternal allele. [provided by RefSeq, Apr 2013]

Chromosome

6 (Chromosome progress)

Cytoband

q25.3

Chromosome location (bp)

160390131 - 160534539

Ensembl

ENSG00000197081 (version 73.37)

Entrez gene

3482

UniProt

P11717 (UniProt - Evidence at protein level)

neXtProt

NX_P11717

Antibodypedia

IGF2R antibodies
 

PROTEIN VIEW

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IGF2R-001
 
IGF2R-005
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IGF2R-001 ENSP00000349437
ENST00000356956
P11717
Show all »
Show » Show » 2491 274.4 Yes 1
IGF2R-005 ENSP00000473880
ENST00000475834
Show » 185 20.4 No 0