SERPINA1

GENERAL INFORMATION

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Gene name

SERPINA1

Gene description

Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1

Protein class

Cancer-related genes
Candidate cardiovascular disease genes
Disease related genes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

15
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enriched (liver)
GTEx:Tissue enriched (liver)

Protein evidence

Evidence at protein level

Protein localization

Distinct positivity in plasma and expression in extracellular matrix in a majority of tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Data reliability

Supportive based on 5 antibodies.
HPA000927 , HPA001292 , CAB013211 , CAB016648 , CAB073396
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Lung

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enriched (liver)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enriched (liver)

Organ

Expression



GENE INFORMATION

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Gene name

SERPINA1 (HGNC Symbol)

Synonyms

A1A, A1AT, AAT, alpha-1-antitrypsin, alpha1AT, PI, PI1

Description

Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema or liver disease. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

14

Cytoband

q32.13

Chromosome location (bp)

94376747 - 94390693

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000197249 (version 78.38)

Entrez gene

5265

UniProt

P01009 (UniProt - Evidence at protein level)

neXtProt

NX_P01009

Antibodypedia

SERPINA1 antibodies


PROTEIN BROWSER

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ENST00000355814
 
ENST00000393087
 
ENST00000393088
 
ENST00000402629
 
ENST00000404814
 
ENST00000437397
 
ENST00000440909
 
ENST00000448921
 
ENST00000449399
 
ENST00000553327
 
ENST00000554720
 
ENST00000556091
 
ENST00000556955
 
ENST00000557118
 
ENST00000557492
 
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PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SERPINA1-001 ENSP00000390299
ENST00000440909
P01009
Show all »
Show » Show » 418 46.7 Yes 0
SERPINA1-002 ENSP00000376803
ENST00000393088
P01009
Show all »
Show » Show » 418 46.7 Yes 0
SERPINA1-003 ENSP00000385960
ENST00000404814
P01009
Show all »
Show » Show » 418 46.7 Yes 0
SERPINA1-004 ENSP00000376802
ENST00000393087
P01009
Show all »
Show » Show » 418 46.7 Yes 0
SERPINA1-006 ENSP00000386094
ENST00000402629
P01009
Show all »
Show » Show » 359 40.3 Yes 0
SERPINA1-007 ENSP00000452452
ENST00000557492
G3V387
Show all »
Show » Show » 144 15.7 Yes 0
SERPINA1-008 ENSP00000416354
ENST00000449399
P01009
Show all »
Show » Show » 418 46.7 Yes 0
SERPINA1-010 ENSP00000451826
ENST00000557118
G3V4I7
Show all »
Show » 22 2.2 Yes 0
SERPINA1-011 ENSP00000451098
ENST00000556955
G3V387
Show all »
Show » Show » 117 12.7 Yes 0
SERPINA1-015 ENSP00000452480
ENST00000553327
G3V5R8
Show all »
Show » Show » 92 9.9 Yes 0
SERPINA1-016 ENSP00000450561
ENST00000554720
G3V2B9
Show all »
Show » Show » 105 11.8 No 0
SERPINA1-017 ENSP00000452169
ENST00000556091
G3V544
Show all »
Show » Show » 156 17.1 Yes 0
SERPINA1-201 ENSP00000348068
ENST00000355814
P01009
Show all »
Show » Show » 418 46.7 Yes 0
SERPINA1-202 ENSP00000408474
ENST00000437397
P01009
Show all »
Show » Show » 418 46.7 Yes 0
SERPINA1-203 ENSP00000416066
ENST00000448921
P01009
Show all »
Show » Show » 418 46.7 Yes 0