MRPL21

GENE INFORMATION

? »

Gene name

MRPL21

Synonyms

Description

mitochondrial ribosomal protein L21 (HGNC Symbol)

Entrez gene summary

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Multiple transcript variants encoding different isoforms were identified through sequence analysis although some may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Jul 2008]

Chromosome

11 (Chromosome progress)

Cytoband

q13.3

Chromosome location (bp)

68658744 - 68671303

Ensembl

ENSG00000197345 (version 73.37)

Entrez gene

219927

UniProt

Q7Z2W9 (UniProt - Evidence at protein level)

neXtProt

NX_Q7Z2W9

Antibodypedia

MRPL21 antibodies
 

PROTEIN VIEW

? »
 
 
 
MRPL21-001
 
MRPL21-003
 
MRPL21-004
 
MRPL21-005
 
MRPL21-006
 
MRPL21-007
 
MRPL21-008
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MRPL21-001 ENSP00000354580
ENST00000362034
Q7Z2W9
Show all »
Show » Show » 205 22.8 Yes 0
MRPL21-003 ENSP00000438837
ENST00000544567
F5H3L0
Show all »
36 3.7 No 0
MRPL21-004 ENSP00000442243
ENST00000541279
F5H7V8
Show all »
Show » 150 16.3 No 0
MRPL21-005 ENSP00000457859
ENST00000567045
H3BUY0
Show all »
Show » 195 21.5 No 0
MRPL21-006 ENSP00000456520
ENST00000565125
F5H4R5
Show all »
Show » 49 5 No 0
MRPL21-007 ENSP00000445009
ENST00000541265
F5H4R5
Show all »
Show » 49 5 No 0
MRPL21-008 ENSP00000389400
ENST00000450904
Q7Z2W9
Show all »
Show » Show » 120 13.7 No 0