MAP3K5

GENE INFORMATION

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Gene name

MAP3K5 (HGNC Symbol)

Synonyms

ASK1, MAPKKK5, MEKK5

Description

mitogen-activated protein kinase kinase kinase 5 (HGNC Symbol)

Entrez gene summary

Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK. [provided by RefSeq, Jul 2008]

Chromosome

6 (Chromosome progress)

Cytoband

q23.3

Chromosome location (bp)

136878185 - 137113656

Ensembl

ENSG00000197442 (version 73.37)

Entrez gene

4217

UniProt

Q99683 (UniProt - Evidence at protein level)

neXtProt

NX_Q99683

Antibodypedia

MAP3K5 antibodies
 

PROTEIN VIEW

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MAP3K5-001
 
MAP3K5-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MAP3K5-001 ENSP00000351908
ENST00000359015
Q99683
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Show » Show » 1374 154.5 No 0
MAP3K5-201 ENSP00000348104
ENST00000355845
A6NIA0
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Show » Show » 621 69.8 No 0