TOPORS

GENERAL INFORMATION

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Gene name

TOPORS

Gene description

Topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase

Protein class

Disease related genes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

General nuclear expression.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Supportive based on 1 antibody.
HPA065661
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

TOPORS (HGNC Symbol)

Synonyms

LUN, RP31, TP53BPL

Description

Topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase (HGNC Symbol)

Entrez gene summary

This gene encodes a nuclear protein which is serine and arginine rich, and contains a RING-type zinc finger domain. It is highly expressed in the testis, and functions as an ubiquitin-protein E3 ligase. Mutations in this gene are associated with retinitis pigmentosa type 31. Alternatively spliced transcript variants, encoding different isoforms, have been observed for this locus. [provided by RefSeq, Sep 2010]

Chromosome

9

Cytoband

p21.1

Chromosome location (bp)

32540544 - 32552553

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000197579 (version 78.38)

Entrez gene

10210

UniProt

Q9NS56 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NS56

Antibodypedia

TOPORS antibodies


PROTEIN BROWSER

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ENST00000360538
 
ENST00000379858
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TOPORS-001 ENSP00000353735
ENST00000360538
Q9NS56
Show all »
Show » Show » 1045 119.2 No 0
TOPORS-002 ENSP00000369187
ENST00000379858
Q9NS56
Show all »
Show » Show » 980 112.3 No 0