PLCG2

GENE INFORMATION

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Gene name

PLCG2

Synonyms

Description

Phospholipase C, gamma 2 (phosphatidylinositol-specific) (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3. [provided by RefSeq, Mar 2014]

Chromosome

16

Cytoband

q23.3

Chromosome location (bp)

81772702 - 81991899

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000197943 (version 75.37)

Entrez gene

5336

UniProt

P16885 (UniProt - Evidence at protein level)

neXtProt

NX_P16885

Antibodypedia

PLCG2 antibodies
 

PROTEIN VIEW

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PLCG2-001
 
PLCG2-002
 
PLCG2-008
 
PLCG2-009
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PLCG2-001 ENSP00000352336
ENST00000359376
P16885
Show all »
Show » Show » 1265 147.9 No 0
PLCG2-002 ENSP00000455956
ENST00000565054
H3BQV5
Show all »
Show » Show » 159 18.2 No 0
PLCG2-008 ENSP00000454536
ENST00000563375
Show » Show » 45 5.1 No 0
PLCG2-009 ENSP00000455533
ENST00000563193
Show » Show » 178 21 No 0