PLCG2

GENE INFORMATION

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Gene name

PLCG2

Synonyms

Description

phospholipase C, gamma 2 (phosphatidylinositol-specific) (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG), using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. [provided by RefSeq, Sep 2011]

Chromosome

16 (Chromosome progress)

Cytoband

q23.3

Chromosome location (bp)

81772702 - 81991899

Ensembl

ENSG00000197943 (version 73.37)

Entrez gene

5336

UniProt

P16885 (UniProt - Evidence at protein level)

neXtProt

NX_P16885

Antibodypedia

PLCG2 antibodies
 

PROTEIN VIEW

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PLCG2-001
 
PLCG2-002
 
PLCG2-008
 
PLCG2-009
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PLCG2-001 ENSP00000352336
ENST00000359376
P16885
Show all »
Show » Show » 1265 147.9 No 0
PLCG2-002 ENSP00000455956
ENST00000565054
H3BQV5
Show all »
Show » 159 18.2 No 0
PLCG2-008 ENSP00000454536
ENST00000563375
Show » 45 5.1 No 0
PLCG2-009 ENSP00000455533
ENST00000563193
Show » 178 21 No 0