SIRPA

GENE INFORMATION

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Gene name

SIRPA (HGNC Symbol)

Synonyms

BIT, CD172a, MFR, MYD-1, P84, PTPNS1, SHPS-1, SHPS1, SIRP, SIRP-ALPHA-1, SIRPalpha, SIRPalpha2

Description

signal-regulatory protein alpha (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene. [provided by RefSeq, Jul 2008]

Chromosome

20 (Chromosome progress)

Cytoband

p13

Chromosome location (bp)

1875154 - 1920543

Ensembl

ENSG00000198053 (version 73.37)

Entrez gene

140885

UniProt

P78324 (UniProt - Evidence at protein level)

neXtProt

NX_P78324

Antibodypedia

SIRPA antibodies
 

PROTEIN VIEW

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SIRPA-001
 
SIRPA-002
 
SIRPA-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SIRPA-001 ENSP00000351621
ENST00000358771
P78324
Show all »
Show » Show » 504 55 Yes 1
SIRPA-002 ENSP00000348307
ENST00000356025
P78324
Show all »
Show » Show » 504 55 Yes 1
SIRPA-003 ENSP00000382941
ENST00000400068
P78324
Show all »
Show » Show » 508 55.4 Yes 1