CD2AP

GENE INFORMATION

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Gene name

CD2AP (HGNC Symbol)

Synonyms

CMS

Description

CD2-associated protein (HGNC Symbol)

Entrez gene summary

This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene is implicated in susceptibility to glomerular disease. [provided by RefSeq, Jul 2008]

Chromosome

6 (Chromosome progress)

Cytoband

p12.3

Chromosome location (bp)

47445525 - 47594999

Ensembl

ENSG00000198087 (version 73.37)

Entrez gene

23607

UniProt

Q9Y5K6 (UniProt - Evidence at protein level)

neXtProt

NX_Q9Y5K6

Antibodypedia

CD2AP antibodies
 

PROTEIN VIEW

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CD2AP-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CD2AP-001 ENSP00000352264
ENST00000359314
Q9Y5K6
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