TMEM116

GENERAL INFORMATION

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Gene name

TMEM116

Gene description

Transmembrane protein 116

Protein class

Predicted membrane proteins
Predicted secreted proteins

Predicted localization

Membrane,Secreted

Number of transcripts

9
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at transcript level

Protein localization

Normal tissues showed weak to moderate cytoplasmic positivity. Ciliated cells in respiratory epithelia and fallopian tube were distinctly stained. Colon, stomach, Purkinje cells and exocrine pancreas exhibited strong staining. Bile duct cells, cardiac myocytes, spleen and glial cells were mainly negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA040720
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Nasopharynx

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

TMEM116 (HGNC Symbol)

Synonyms

FLJ90167

Description

Transmembrane protein 116 (HGNC Symbol)

Entrez gene summary

Chromosome

12

Cytoband

q24.13

Chromosome location (bp)

111931282 - 112013185

Protein evidence

Evidence at transcript level (all genes)

Ensembl

ENSG00000198270 (version 78.38)

Entrez gene

89894

UniProt

Q8NCL8 (UniProt - Evidence at transcript level)

neXtProt

NX_Q8NCL8

Antibodypedia

TMEM116 antibodies


PROTEIN BROWSER

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ENST00000355445
 
ENST00000546962
 
ENST00000549425
 
ENST00000549537
 
ENST00000550037
 
ENST00000550233
 
ENST00000550800
 
ENST00000550831
 
ENST00000552374
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TMEM116-001 ENSP00000447731
ENST00000552374
Q8NCL8
Show all »
Show » Show » 337 38 No 4
TMEM116-003 ENSP00000449163
ENST00000549537
G3V1Z3
Show all »
Show » Show » 151 17.3 No 1
TMEM116-005 ENSP00000450377
ENST00000550831
Q8NCL8
Show all »
Show » Show » 245 27.5 No 2
TMEM116-007 ENSP00000347620
ENST00000355445
Q8NCL8
Show all »
Show » Show » 302 33.8 Yes 3
TMEM116-009 ENSP00000450060
ENST00000550233
F8VQZ8
Show all »
Show » 51 5.8 Yes 1
TMEM116-010 ENSP00000449774
ENST00000549425
F8VWU6
Show all »
Show » 106 12 No 1
TMEM116-012 ENSP00000446516
ENST00000550037
F8VNZ8
Show all »
Show » 175 19.6 No 2
TMEM116-013 ENSP00000446766
ENST00000546962
F8W1L7
Show all »
Show » 74 8.1 Yes 0
TMEM116-014 ENSP00000474027
ENST00000550800
S4R388
Show all »
Show » 104 11.4 No 1