MGEA5

GENERAL INFORMATION

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Gene name

MGEA5

Gene description

Meningioma expressed antigen 5 (hyaluronidase)

Protein class

Enzymes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

5
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

A majority of normal tissues displayed weak to moderate cytoplasmic immunoreactivity combined with nuclear staining in a few cases. Spermatogonia in seminiferous ducts showed strong cytoplasmic staining. The lung, liver, pancreatic islets, skin, placental trophoblasts, glial cells and smooth muscle were negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA036141
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

MGEA5 (HGNC Symbol)

Synonyms

MEA5, NCOAT, OGA

Description

Meningioma expressed antigen 5 (hyaluronidase) (HGNC Symbol)

Entrez gene summary

The dynamic modification of cytoplasmic and nuclear proteins by O-linked N-acetylglucosamine (O-GlcNAc) addition and removal on serine and threonine residues is catalyzed by OGT (MIM 300255), which adds O-GlcNAc, and MGEA5, a glycosidase that removes O-GlcNAc modifications (Gao et al., 2001 [PubMed 11148210]).[supplied by OMIM, Mar 2008]

Chromosome

10

Cytoband

q24.32

Chromosome location (bp)

101784443 - 101818465

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000198408 (version 78.38)

Entrez gene

10724

UniProt

O60502 (UniProt - Evidence at protein level)

neXtProt

NX_O60502

Antibodypedia

MGEA5 antibodies


PROTEIN BROWSER

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ENST00000357797
 
ENST00000361464
 
ENST00000370094
 
ENST00000429860
 
ENST00000439817
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MGEA5-002 ENSP00000414235
ENST00000429860
H7C3X0
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Show » 256 29.7 No 0
MGEA5-003 ENSP00000354850
ENST00000361464
O60502
Show all »
Show » Show » 916 102.9 No 0
MGEA5-004 ENSP00000350445
ENST00000357797
O60502
Show all »
Show » Show » 849 95.3 No 0
MGEA5-005 ENSP00000359112
ENST00000370094
O60502
Show all »
Show » Show » 677 76.2 No 0
MGEA5-201 ENSP00000409973
ENST00000439817
O60502
Show all »
Show » Show » 863 96.9 No 0