YTHDF2

GENE INFORMATION

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Gene name

YTHDF2 (HGNC Symbol)

Synonyms

HGRG8, NY-REN-2

Description

YTH domain family, member 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the YTH (YT521-B homology) superfamily containing YTH domain. The YTH domain is typical for the eukaryotes and is particularly abundant in plants. The YTH domain is usually located in the middle of the protein sequence and may function in binding to RNA. In addition to a YTH domain, this protein has a proline rich region which may be involved in signal transduction. An Alu-rich domain has been identified in one of the introns of this gene, which is thought to be associated with human longevity. In addition, reciprocal translocations between this gene and the Runx1 (AML1) gene on chromosome 21 has been observed in patients with acute myeloid leukemia. This gene was initially mapped to chromosome 14, which was later turned out to be a pseudogene. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Oct 2012]

Chromosome

1 (Chromosome progress)

Cytoband

p35.3

Chromosome location (bp)

29063133 - 29096287

Ensembl

ENSG00000198492 (version 73.37)

Entrez gene

51441

UniProt

Q9Y5A9 (UniProt - Evidence at protein level)

neXtProt

NX_Q9Y5A9

Antibodypedia

YTHDF2 antibodies
 

PROTEIN VIEW

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YTHDF2-001
 
YTHDF2-003
 
YTHDF2-006
 
YTHDF2-201
 
YTHDF2-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

YTHDF2-001 ENSP00000362918
ENST00000373812
Q9Y5A9
Show all »
Show » 579 62.3 No 0
YTHDF2-003 ENSP00000474446
ENST00000474884
200 21 No 0
YTHDF2-006 ENSP00000474784
ENST00000496288
241 24.9 No 0
YTHDF2-201 ENSP00000439394
ENST00000541996
Q9Y5A9
Show all »
Show » 529 56.9 No 0
YTHDF2-202 ENSP00000444660
ENST00000542507
Q9Y5A9
Show all »
Show » 579 62.3 No 0