HLA-DRB5

GENERAL INFORMATION

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Gene name

HLA-DRB5

Gene description

Major histocompatibility complex, class II, DR beta 5

Protein class

Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (lung)
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in subsets of immune cells.

ANTIBODY RELIABILITY

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Data reliability
description

Caution, targets protein from more than one gene. Presumed off target binding observed and disregarded. Antibody staining in cells/structures not annotated, view images.

Data reliability

Supportive based on 1 antibody.
HPA043151
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (lung)

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

HLA-DRB5

Synonyms

Description

Major histocompatibility complex, class II, DR beta 5 (HGNC Symbol)

Entrez gene summary

HLA-DRB5 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB5 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq, Jul 2008]

Chromosome

6

Cytoband

p21.32

Chromosome location (bp)

32517343 - 32530287

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000198502 (version 78.38)

Entrez gene

3127

UniProt

Q30154 (UniProt - Evidence at protein level)

neXtProt

NX_Q30154

Antibodypedia

HLA-DRB5 antibodies


PROTEIN BROWSER

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ENST00000374975
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HLA-DRB5-001 ENSP00000364114
ENST00000374975
Q30154
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