PLN

GENERAL INFORMATION

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Gene name

PLN

Gene description

Phospholamban

Protein class

Disease related genes
Potential drug targets
Predicted membrane proteins
Transporters

Predicted localization

Membrane

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enriched (heart muscle)
GTEx:Tissue enhanced (heart muscle)

Protein evidence

Evidence at protein level

Protein localization

High and selective expression in cytoplasm and nuclear membranes of skeletal, heart and smooth muscle.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining consistent with RNA expression data.

Data reliability

Supportive based on 2 antibodies.
HPA026900 , CAB005597
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Heart muscle

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enriched (heart muscle)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (heart muscle)

Organ

Expression



GENE INFORMATION

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Gene name

PLN (HGNC Symbol)

Synonyms

CMD1P, PLB

Description

Phospholamban (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure. [provided by RefSeq, Jul 2008]

Chromosome

6

Cytoband

q22.31

Chromosome location (bp)

118548298 - 118560730

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000198523 (version 78.38)

Entrez gene

5350

UniProt

P26678 (UniProt - Evidence at protein level)

neXtProt

NX_P26678

Antibodypedia

PLN antibodies


PROTEIN BROWSER

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ENST00000357525
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PLN-001 ENSP00000350132
ENST00000357525
P26678
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