PLN

GENE INFORMATION

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Gene name

PLN (HGNC Symbol)

Synonyms

CMD1P, PLB

Description

phospholamban (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure. [provided by RefSeq, Jul 2008]

Chromosome

6 (Chromosome progress)

Cytoband

q22.31

Chromosome location (bp)

118869461 - 118881893

Ensembl

ENSG00000198523 (version 73.37)

Entrez gene

5350

UniProt

P26678 (UniProt - Evidence at protein level)

neXtProt

NX_P26678

Antibodypedia

PLN antibodies
 

PROTEIN VIEW

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PLN-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PLN-001 ENSP00000350132
ENST00000357525
P26678
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