AKR1C4

GENE INFORMATION

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Gene name

AKR1C4 (HGNC Symbol)

Synonyms

3-alpha-HSD, C11, CDR, CHDR, DD4, HAKRA, MGC22581

Description

aldo-keto reductase family 1, member C4 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq, Jul 2008]

Chromosome

10 (Chromosome progress)

Cytoband

p15.1

Chromosome location (bp)

5237425 - 5260912

Ensembl

ENSG00000198610 (version 73.37)

Entrez gene

1109

UniProt

P17516 (UniProt - Evidence at protein level)

neXtProt

NX_P17516

Antibodypedia

AKR1C4 antibodies
 

PROTEIN VIEW

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AKR1C4-001
 
AKR1C4-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

AKR1C4-001 ENSP00000369814
ENST00000380448
P17516
Show all »
Show » Show » 323 37.1 No 0
AKR1C4-201 ENSP00000263126
ENST00000263126
P17516
Show all »
Show » Show » 323 37.1 No 0