MDM4

GENE INFORMATION

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Gene name

MDM4 (HGNC Symbol)

Synonyms

HDMX, MDMX

Description

MDM4, p53 regulator (HGNC Symbol)

Entrez gene summary

This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011]

Chromosome

1

Cytoband

q32.1

Chromosome location (bp)

204516379 - 204558120

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000198625 (version 78.38)

Entrez gene

4194

UniProt

O15151 (UniProt - Evidence at protein level)

neXtProt

NX_O15151

Antibodypedia

MDM4 antibodies
 

PROTEIN VIEW

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MDM4-001
 
MDM4-006
 
MDM4-007
 
MDM4-009
 
MDM4-201
 
MDM4-202
 
MDM4-203
 
MDM4-204
 
MDM4-205
 
MDM4-206
 
MDM4-207
 
MDM4-208
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MDM4-001 ENSP00000356150
ENST00000367182
O15151
Show all »
Show » Show » 490 54.9 No 0
MDM4-006 ENSP00000356147
ENST00000367179
Q5T0Y2
Show all »
Show » Show » 213 24.2 No 0
MDM4-007 ENSP00000395254
ENST00000444261
Q5T0Y3
Show all »
Show » Show » 171 19.6 No 0
MDM4-009 ENSP00000356148
ENST00000367180
Q5T0Y4
Show all »
Show » Show » 131 14.6 No 0
MDM4-201 ENSP00000356151
ENST00000367183
O15151
Show all »
Show » Show » 164 18.2 No 0
MDM4-202 ENSP00000375811
ENST00000391947
Q68DC0
Show all »
Show » Show » 140 15.9 No 0
MDM4-203 ENSP00000396840
ENST00000454264
O15151
Show all »
Show » Show » 440 49.5 No 0
MDM4-204 ENSP00000443816
ENST00000507825
Q68DC0
Show all »
Show » Show » 140 15.9 No 0
MDM4-205 ENSP00000478080
ENST00000612738
Show » Show » 267 29.9 No 0
MDM4-206 ENSP00000482388
ENST00000614459
Show » Show » 392 44 No 0
MDM4-207 ENSP00000478581
ENST00000616250
Show » Show » 116 12.8 No 0
MDM4-208 ENSP00000482479
ENST00000621032
Q6MZR7
Show all »
Show » Show » 153 17.3 No 0