MDM4

GENERAL INFORMATION

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Gene name

MDM4

Gene description

MDM4, p53 regulator

Protein class

Cancer-related genes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

12
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Moderate to strong cytoplasmic and nuclear positivity was seen in most normal tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA018919
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

MDM4 (HGNC Symbol)

Synonyms

HDMX, MDMX

Description

MDM4, p53 regulator (HGNC Symbol)

Entrez gene summary

This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011]

Chromosome

1

Cytoband

q32.1

Chromosome location (bp)

204516379 - 204558120

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000198625 (version 78.38)

Entrez gene

4194

UniProt

O15151 (UniProt - Evidence at protein level)

neXtProt

NX_O15151

Antibodypedia

MDM4 antibodies


PROTEIN BROWSER

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ENST00000367179
 
ENST00000367180
 
ENST00000367182
 
ENST00000367183
 
ENST00000391947
 
ENST00000444261
 
ENST00000454264
 
ENST00000507825
 
ENST00000612738
 
ENST00000614459
 
ENST00000616250
 
ENST00000621032
 
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PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MDM4-001 ENSP00000356150
ENST00000367182
O15151
Show all »
Show » Show » 490 54.9 No 0
MDM4-006 ENSP00000356147
ENST00000367179
Q5T0Y2
Show all »
Show » Show » 213 24.2 No 0
MDM4-007 ENSP00000395254
ENST00000444261
Q5T0Y3
Show all »
Show » Show » 171 19.6 No 0
MDM4-009 ENSP00000356148
ENST00000367180
Q5T0Y4
Show all »
Show » Show » 131 14.6 No 0
MDM4-201 ENSP00000356151
ENST00000367183
O15151
Show all »
Show » Show » 164 18.2 No 0
MDM4-202 ENSP00000375811
ENST00000391947
Q68DC0
Show all »
Show » Show » 140 15.9 No 0
MDM4-203 ENSP00000396840
ENST00000454264
O15151
Show all »
Show » Show » 440 49.5 No 0
MDM4-204 ENSP00000443816
ENST00000507825
Q68DC0
Show all »
Show » Show » 140 15.9 No 0
MDM4-205 ENSP00000478080
ENST00000612738
Show » Show » 267 29.9 No 0
MDM4-206 ENSP00000482388
ENST00000614459
Show » Show » 392 44 No 0
MDM4-207 ENSP00000478581
ENST00000616250
Show » Show » 116 12.8 No 0
MDM4-208 ENSP00000482479
ENST00000621032
Q6MZR7
Show all »
Show » Show » 153 17.3 No 0