LPA

GENE INFORMATION

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Gene name

LPA (HGNC Symbol)

Synonyms

LP

Description

lipoprotein, Lp(a) (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a serine proteinase that inhibits the activity of tissue-type plasminogen activator I. The encoded protein constitutes a substantial portion of lipoprotein(a) and is proteolytically cleaved, resulting in fragments that attach to atherosclerotic lesions and promote thrombogenesis. Elevated plasma levels of this protein are linked to atherosclerosis. Depending on the individual, the encoded protein contains 2-43 copies of kringle-type domains. The allele represented here contains 15 copies of the kringle-type repeats and corresponds to that found in the reference genome sequence. [provided by RefSeq, Dec 2009]

Chromosome

6 (Chromosome progress)

Cytoband

q25.3

Chromosome location (bp)

160952515 - 161087407

Ensembl

ENSG00000198670 (version 73.37)

Entrez gene

4018

UniProt

P08519 (UniProt - Evidence at protein level)

neXtProt

NX_P08519

Antibodypedia

LPA antibodies
 

PROTEIN VIEW

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LPA-001
 
LPA-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

LPA-001 ENSP00000321334
ENST00000316300
P08519
Show all »
Show » Show » 2040 226.5 Yes 0
LPA-201 ENSP00000395608
ENST00000447678
P08519
Show all »
Show » Show » 2040 226.5 Yes 0