F5

GENE INFORMATION

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Gene name

F5

Synonyms

Description

coagulation factor V (proaccelerin, labile factor) (HGNC Symbol)

Entrez gene summary

This gene encodes an essential cofactor of the blood coagulation cascade. This factor circulates in plasma, and is converted to the active form by the release of the activation peptide by thrombin during coagulation. This generates a heavy chain and a light chain which are held together by calcium ions. The activated protein is a cofactor that participates with activated coagulation factor X to activate prothrombin to thrombin. Defects in this gene result in either an autosomal recessive hemorrhagic diathesis or an autosomal dominant form of thrombophilia, which is known as activated protein C resistance. [provided by RefSeq, Oct 2008]

Chromosome

1 (Chromosome progress)

Cytoband

q24.2

Chromosome location (bp)

169483404 - 169555826

Ensembl

ENSG00000198734 (version 73.37)

Entrez gene

2153

UniProt

P12259 (UniProt - Evidence at protein level)

neXtProt

NX_P12259

Antibodypedia

F5 antibodies
 

PROTEIN VIEW

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F5-001
 
F5-002
 
F5-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

F5-001 ENSP00000356771
ENST00000367797
P12259
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Show » Show » 2224 251.7 Yes 0
F5-002 ENSP00000356770
ENST00000367796
P12259
Show all »
Show » Show » 2229 252.2 Yes 0
F5-201 ENSP00000439664
ENST00000546081
B4DU26
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332 37.7 No 0