CD3E

GENE INFORMATION

? »

Gene name

CD3E

Synonyms

Description

CD3e molecule, epsilon (CD3-TCR complex) (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008]

Chromosome

11 (Chromosome progress)

Cytoband

q23.3

Chromosome location (bp)

118175260 - 118186890

Ensembl

ENSG00000198851 (version 73.37)

Entrez gene

916

UniProt

P07766 (UniProt - Evidence at protein level)

neXtProt

NX_P07766

Antibodypedia

CD3E antibodies
 

PROTEIN VIEW

? »
 
 
 
CD3E-001
 
CD3E-007
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CD3E-001 ENSP00000354566
ENST00000361763
P07766
Show all »
Show » Show » 207 23.1 Yes 1
CD3E-007 ENSP00000433975
ENST00000528600
E9PSH8
Show all »
Show » Show » 201 22.6 Yes 1