MAP3K3

GENE INFORMATION

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Gene name

MAP3K3 (HGNC Symbol)

Synonyms

MAPKKK3, MEKK3

Description

mitogen-activated protein kinase kinase kinase 3 (HGNC Symbol)

Entrez gene summary

This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Chromosome

17 (Chromosome progress)

Cytoband

q23.3

Chromosome location (bp)

61699775 - 61773663

Ensembl

ENSG00000198909 (version 73.37)

Entrez gene

4215

UniProt

Q99759 (UniProt - Evidence at protein level)

neXtProt

NX_Q99759

Antibodypedia

MAP3K3 antibodies
 

PROTEIN VIEW

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MAP3K3-001
 
MAP3K3-002
 
MAP3K3-004
 
MAP3K3-005
 
MAP3K3-006
 
MAP3K3-007
 
MAP3K3-008
 
MAP3K3-010
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MAP3K3-001 ENSP00000354927
ENST00000361357
Q99759
Show all »
Show » Show » 657 74.1 No 0
MAP3K3-002 ENSP00000464130
ENST00000584573
J3QRB6
Show all »
Show » Show » 653 73.7 No 0
MAP3K3-004 ENSP00000354485
ENST00000361733
Q99759
Show all »
Show » Show » 626 70.9 No 0
MAP3K3-005 ENSP00000462086
ENST00000577395
J3KRN4
Show all »
Show » Show » 622 70.5 No 0
MAP3K3-006 ENSP00000462917
ENST00000577597
J3KTC4
Show all »
56 6.3 No 0
MAP3K3-007 ENSP00000461988
ENST00000579585
Q99759
Show all »
Show » Show » 657 74.1 No 0
MAP3K3-008 ENSP00000464532
ENST00000585302
31 3.3 No 0
MAP3K3-010 ENSP00000464482
ENST00000581732
42 4.6 No 0