APRT

GENE INFORMATION

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Gene name

APRT

Synonyms

Description

adenine phosphoribosyltransferase (HGNC Symbol)

Entrez gene summary

Adenine phosphoribosyltransferase belongs to the purine/pyrimidine phosphoribosyltransferase family. A conserved feature of this gene is the distribution of CpG dinucleotides. This enzyme catalyzes the formation of AMP and inorganic pyrophosphate from adenine and 5-phosphoribosyl-1-pyrophosphate (PRPP). It also produces adenine as a by-product of the polyamine biosynthesis pathway. A homozygous deficiency in this enzyme causes 2,8-dihydroxyadenine urolithiasis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

16 (Chromosome progress)

Cytoband

q24.3

Chromosome location (bp)

88875747 - 88878352

Ensembl

ENSG00000198931 (version 73.37)

Entrez gene

353

UniProt

P07741 (UniProt - Evidence at protein level)

neXtProt

NX_P07741

Antibodypedia

APRT antibodies
 

PROTEIN VIEW

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APRT-001
 
APRT-002
 
APRT-007
 
APRT-008
 
APRT-009
 
APRT-010
 
APRT-011
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

APRT-001 ENSP00000367615
ENST00000378364
P07741
Show all »
Show » Show » 180 19.6 No 0
APRT-002 ENSP00000397007
ENST00000426324
P07741
Show all »
Show » Show » 134 14.6 No 0
APRT-007 ENSP00000455749
ENST00000567713
H3BQF1
Show all »
Show » Show » 149 16.4 No 0
APRT-008 ENSP00000455692
ENST00000569616
Show » Show » 162 17.5 No 0
APRT-009 ENSP00000456905
ENST00000568319
H3BSW3
Show all »
Show » 63 6.9 No 0
APRT-010 ENSP00000457964
ENST00000567391
H3BSW3
Show all »
Show » 63 6.9 No 0
APRT-011 ENSP00000456012
ENST00000563655
H3BQZ9
Show all »
Show » Show » 153 16.6 No 0