CR1

GENE INFORMATION

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Gene name

CR1 (HGNC Symbol)

Synonyms

CD35, KN

Description

complement component (3b/4b) receptor 1 (Knops blood group) (HGNC Symbol)

Entrez gene summary

This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized. [provided by RefSeq, Jul 2008]

Chromosome

1 (Chromosome progress)

Cytoband

q32.2

Chromosome location (bp)

207669492 - 207813992

Ensembl

ENSG00000203710 (version 73.37)

Entrez gene

1378

UniProt

P17927 (UniProt - Evidence at protein level)

neXtProt

NX_P17927

Antibodypedia

CR1 antibodies
 

PROTEIN VIEW

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CR1-001
 
CR1-002
 
CR1-003
 
CR1-007
 
CR1-010
 
CR1-011
 
CR1-012
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CR1-001 ENSP00000383744
ENST00000400960
P17927
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Show » Show » 2039 223.7 Yes 1
CR1-002 ENSP00000356018
ENST00000367051
P17927
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Show » Show » 2039 223.6 Yes 1
CR1-003 ENSP00000356020
ENST00000367053
P17927
Show all »
Show » Show » 2039 223.7 Yes 1
CR1-007 ENSP00000356019
ENST00000367052
Q5SR44
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Show » 2039 223.7 Yes 1
CR1-010 ENSP00000436139
ENST00000534202
E9PQN4
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Show » 1151 126 Yes 0
CR1-011 ENSP00000434718
ENST00000529814
Show » 661 72.9 Yes 1
CR1-012 ENSP00000356016
ENST00000367049
E9PDY4
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Show » 2489 272.9 Yes 1