DAXX

GENE INFORMATION

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Gene name

DAXX (HGNC Symbol)

Synonyms

DAP6

Description

death-domain associated protein (HGNC Symbol)

Entrez gene summary

This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]

Chromosome

6 (Chromosome progress)

Cytoband

p21.32

Chromosome location (bp)

33286335 - 33297046

Ensembl

ENSG00000204209 (version 73.37)

Entrez gene

1616

UniProt

Q9UER7 (UniProt - Evidence at protein level)

neXtProt

NX_Q9UER7

Antibodypedia

DAXX antibodies
 

PROTEIN VIEW

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DAXX-001
 
DAXX-002
 
DAXX-005
 
DAXX-007
 
DAXX-011
 
DAXX-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DAXX-001 ENSP00000363668
ENST00000374542
Q9UER7
Show all »
Show » Show » 740 81.4 No 0
DAXX-002 ENSP00000266000
ENST00000266000
Q9UER7
Show all »
Show » Show » 740 81.4 No 0
DAXX-005 ENSP00000408499
ENST00000453407
Q5STR5
Show all »
Show » 130 14.2 No 0
DAXX-007 ENSP00000406008
ENST00000446403
Q4VX54
Show all »
Show » 178 19.1 No 0
DAXX-011 ENSP00000390008
ENST00000446511
A2AB94
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Show » 48 4.8 No 0
DAXX-201 ENSP00000396876
ENST00000414083
Q9UER7
Show all »
Show » Show » 665 73.6 No 0