PSMB8

GENE INFORMATION

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Gene name

PSMB8 (HGNC Symbol)

Synonyms

beta5i, D6S216E, LMP7, PSMB5i, RING10

Description

proteasome (prosome, macropain) subunit, beta type, 8 (HGNC Symbol)

Entrez gene summary

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit. [provided by RefSeq, Jul 2008]

Chromosome

6 (Chromosome progress)

Cytoband

p21.32

Chromosome location (bp)

32808494 - 32812480

Ensembl

ENSG00000204264 (version 73.37)

Entrez gene

5696

UniProt

P28062 (UniProt - Evidence at protein level)

neXtProt

NX_P28062

Antibodypedia

PSMB8 antibodies
 

PROTEIN VIEW

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PSMB8-001
 
PSMB8-002
 
PSMB8-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PSMB8-001 ENSP00000364015
ENST00000374881
P28062
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Show » Show » 272 29.8 No 0
PSMB8-002 ENSP00000364016
ENST00000374882
P28062
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Show » Show » 276 30.4 No 0
PSMB8-004 ENSP00000378748
ENST00000395339
Q5JNW7
Show all »
Show » 252 27.9 No 0