TAP2

GENERAL INFORMATION

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Gene name

TAP2

Gene description

Transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)

Protein class

Disease related genes
Potential drug targets
Predicted membrane proteins
Transporters

Predicted localization

Membrane

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression mainly in subsets of immune cells in several tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly not consistent with RNA expression data. Caution, targets protein from more than one gene.

Data reliability

Uncertain based on 1 antibody.
HPA001312
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Kidney

Urinary bladder

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

TAP2 (HGNC Symbol)

Synonyms

ABCB3, D6S217E, PSF2, RING11

Description

Transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) (HGNC Symbol)

Entrez gene summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules. [provided by RefSeq, Feb 2014]

Chromosome

6

Cytoband

p21.32

Chromosome location (bp)

32821833 - 32838780

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000204267 (version 78.38)

Entrez gene

6891

UniProt

Q03519 (UniProt - Evidence at protein level)

neXtProt

NX_Q03519

Antibodypedia

TAP2 antibodies


PROTEIN BROWSER

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ENST00000374897
 
ENST00000374899
 
ENST00000620123
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TAP2-001 ENSP00000364032
ENST00000374897
Q03519
Show all »
Show » Show » 686 75.7 No 8
TAP2-002 ENSP00000364034
ENST00000374899
Q03519
Show all »
Show » Show » 653 72 No 8
TAP2-201 ENSP00000481712
ENST00000620123
Q5JNW1
Show all »
Show » Show » 702 77.6 No 8