TAP2

GENE INFORMATION

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Gene name

TAP2 (HGNC Symbol)

Synonyms

ABCB3, D6S217E, PSF2, RING11

Description

transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) (HGNC Symbol)

Entrez gene summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces two products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules. [provided by RefSeq, Jul 2008]

Chromosome

6 (Chromosome progress)

Cytoband

p21.32

Chromosome location (bp)

32789610 - 32806557

Ensembl

ENSG00000204267 (version 73.37)

Entrez gene

6891

UniProt

Q03519 (UniProt - Evidence at protein level)

neXtProt

NX_Q03519

Antibodypedia

TAP2 antibodies
 

PROTEIN VIEW

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TAP2-001
 
TAP2-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TAP2-001 ENSP00000364032
ENST00000374897
Q03519
Show all »
Show » Show » 686 75.7 No 8
TAP2-002 ENSP00000364034
ENST00000374899
Q03519
Show all »
Show » Show » 653 72 No 8