The gene information section lists the gene name (HUGO Gene Nomenclature Committee (HGNC) name if available), any approved gene synonyms, Ensembl gene description, and the Entrez gene summary from the National Center for Biotechnology Information.
The chromosomal and cytoband location of the gene according to Ensembl is reported together with the Ensembl gene identifier and Ensembl database version. The Entrez gene identifier for the gene is also given. If any of the protein products of the gene is linked to a UniProt KB/SWISS-PROT entry, links to the UniProt and the neXtProt databases for these proteins are displayed.
Gene name
TAP2 (HGNC Symbol)
Synonyms
ABCB3, D6S217E, PSF2, RING11
Description
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) (HGNC Symbol)
Entrez gene summary
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces two products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules. [provided by RefSeq, Jul 2008]
The protein view displays protein features. The tabs at the top of the protein view section can be used to switch between the different splice variants encoded by this gene. The mouse over function displays additional data for the features in the protein view.
At the top of the protein view, the maximum percent sequence identity of the protein to all other proteins from other human genes is shown, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50) (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0 and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Common (purple) and unique (grey) regions between alternative processed transcripts from the same gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
The protein information section displays the alternative protein-coding transcripts (splice variants) encoded by this gene, according to the Ensembl database.
The ENSP identifier links to the Ensembl website for that protein, and the ENST identifier links to the Ensembl website for that transcript. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes to which this protein has been assigned are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column.
The length of the protein (amino acid residues) (according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0 and Phobius and predicted transmembrane region(s) (according to MDM) are also reported.
GO:0001916 [positive regulation of T cell mediated cytotoxicity] GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] GO:0002481 [antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent] GO:0002485 [antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent] GO:0002489 [antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent] GO:0002591 [positive regulation of antigen processing and presentation of peptide antigen via MHC class I] GO:0005215 [transporter activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0015197 [peptide transporter activity] GO:0015421 [oligopeptide-transporting ATPase activity] GO:0015433 [peptide antigen-transporting ATPase activity] GO:0015833 [peptide transport] GO:0016021 [integral to membrane] GO:0019060 [intracellular transport of viral proteins in host cell] GO:0019885 [antigen processing and presentation of endogenous peptide antigen via MHC class I] GO:0030176 [integral to endoplasmic reticulum membrane] GO:0030670 [phagocytic vesicle membrane] GO:0042288 [MHC class I protein binding] GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] GO:0042605 [peptide antigen binding] GO:0042825 [TAP complex] GO:0046967 [cytosol to ER transport] GO:0046968 [peptide antigen transport] GO:0046978 [TAP1 binding] GO:0046979 [TAP2 binding] GO:0046980 [tapasin binding] GO:0055085 [transmembrane transport]
GO:0001916 [positive regulation of T cell mediated cytotoxicity] GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] GO:0002481 [antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent] GO:0002485 [antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent] GO:0002489 [antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent] GO:0002591 [positive regulation of antigen processing and presentation of peptide antigen via MHC class I] GO:0005215 [transporter activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0015197 [peptide transporter activity] GO:0015421 [oligopeptide-transporting ATPase activity] GO:0015433 [peptide antigen-transporting ATPase activity] GO:0015833 [peptide transport] GO:0016021 [integral to membrane] GO:0019060 [intracellular transport of viral proteins in host cell] GO:0019885 [antigen processing and presentation of endogenous peptide antigen via MHC class I] GO:0030176 [integral to endoplasmic reticulum membrane] GO:0030670 [phagocytic vesicle membrane] GO:0042288 [MHC class I protein binding] GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] GO:0042605 [peptide antigen binding] GO:0042825 [TAP complex] GO:0046967 [cytosol to ER transport] GO:0046968 [peptide antigen transport] GO:0046978 [TAP1 binding] GO:0046979 [TAP2 binding] GO:0046980 [tapasin binding] GO:0055085 [transmembrane transport]
