HLA-DRA

GENE INFORMATION

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Gene name

HLA-DRA (HGNC Symbol)

Synonyms

HLA-DRA1

Description

major histocompatibility complex, class II, DR alpha (HGNC Symbol)

Entrez gene summary

HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. [provided by RefSeq, Jul 2008]

Chromosome

6 (Chromosome progress)

Cytoband

p21.32

Chromosome location (bp)

32407619 - 32412823

Ensembl

ENSG00000204287 (version 73.37)

Entrez gene

3122

UniProt

P01903 (UniProt - Evidence at protein level)

neXtProt

NX_P01903

Antibodypedia

HLA-DRA antibodies
 

PROTEIN VIEW

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HLA-DRA-001
 
HLA-DRA-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HLA-DRA-001 ENSP00000378786
ENST00000395388
P01903
Show all »
Show » Show » 254 28.6 Yes 1
HLA-DRA-002 ENSP00000364121
ENST00000374982
Q30118
Show all »
Show » Show » 229 25.9 Yes 1