CASP12

GENE INFORMATION

? »

Gene name

CASP12 (HGNC Symbol)

Synonyms

CASP12P1

Description

caspase 12 (gene/pseudogene) (HGNC Symbol)

Entrez gene summary

Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Feb 2011]

Chromosome

11 (Chromosome progress)

Cytoband

q22.3

Chromosome location (bp)

104756445 - 104769397

Ensembl

ENSG00000204403 (version 73.37)

Entrez gene

100506742

UniProt

Q6UXS9 (UniProt - Evidence at transcript level)

neXtProt

NX_Q6UXS9

Antibodypedia

CASP12 antibodies
 

PROTEIN VIEW

? »
 
 
 « 
 
CASP12-001
 
CASP12-002
 
CASP12-003
 
CASP12-004
 
CASP12-005
 
CASP12-006
 
CASP12-007
 
CASP12-008
 
CASP12-009
 
CASP12-010
 
CASP12-011
 
 » 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CASP12-001 ENSP00000421408
ENST00000458137
Q6UXS9
Show all »
Show » Show » 168 19.1 No 0
CASP12-002 ENSP00000424038
ENST00000375726
Q6UXS9
Show all »
Show » Show » 341 38.9 No 0
CASP12-003 ENSP00000426427
ENST00000447913
D6RG27
Show all »
Show » Show » 140 15.6 No 0
CASP12-004 ENSP00000425652
ENST00000446862
D6RJG1
Show all »
Show » 277 31 No 0
CASP12-005 ENSP00000423970
ENST00000441710
D6RBW4
Show all »
Show » 295 33.6 No 0
CASP12-006 ENSP00000427437
ENST00000433738
D6RIR9
Show all »
Show » Show » 142 16.2 No 0
CASP12-007 ENSP00000423899
ENST00000448103
D6RC33
Show all »
Show » 224 25.1 No 0
CASP12-008 ENSP00000427128
ENST00000422698
Q6UXS9
Show all »
Show » Show » 341 38.9 No 0
CASP12-009 ENSP00000424963
ENST00000417998
Q6UXS9
Show all »
Show » Show » 168 19.1 No 0
CASP12-010 ENSP00000421815
ENST00000494737
D6RAQ6
Show all »
Show » 226 25.6 No 0
CASP12-011 ENSP00000426566
ENST00000508062
Q6UXS9
Show all »
Show » Show » 257 29.4 No 0