MSH5

GENE INFORMATION

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Gene name

MSH5

Synonyms

Description

mutS homolog 5 (E. coli) (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the mutS family of proteins that are involved in DNA mismatch repair and meiotic recombination. This protein is similar to a Saccharomyces cerevisiae protein that participates in segregation fidelity and crossing-over events during meiosis. This protein plays a role in promoting ionizing radiation-induced apoptosis. This protein forms hetero-oligomers with another member of this family, mutS homolog 4. Polymorphisms in this gene have been linked to various human diseases, including IgA deficiency, common variable immunodeficiency, and premature ovarian failure. Alternative splicing results multiple transcript variants. Read-through transcription also exists between this gene and the downstream chromosome 6 open reading frame 26 (C6orf26) gene. [provided by RefSeq, Feb 2011]

Chromosome

6 (Chromosome progress)

Cytoband

p21.33

Chromosome location (bp)

31707725 - 31732622

Ensembl

ENSG00000204410 (version 73.37)

Entrez gene

4439

UniProt

O43196 (UniProt - Evidence at protein level)

neXtProt

NX_O43196

Antibodypedia

MSH5 antibodies
 

PROTEIN VIEW

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 « 
 
MSH5-001
 
MSH5-002
 
MSH5-004
 
MSH5-005
 
MSH5-006
 
MSH5-008
 
MSH5-010
 
MSH5-011
 
MSH5-012
 
MSH5-017
 
MSH5-018
 
MSH5-021
 
MSH5-201
 
MSH5-202
 
MSH5-203
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MSH5-001 ENSP00000364908
ENST00000375755
O43196
Show all »
Show » Show » 834 92.9 No 0
MSH5-002 ENSP00000364903
ENST00000375750
O43196
Show all »
Show » Show » 834 92.9 No 0
MSH5-004 ENSP00000364855
ENST00000375703
O43196
Show all »
Show » Show » 835 93 No 0
MSH5-005 ENSP00000364892
ENST00000375740
O43196
Show all »
Show » Show » 822 91.9 No 0
MSH5-006 ENSP00000379194
ENST00000395853
A2ABF0
Show all »
Show » Show » 508 56.1 Yes 0
MSH5-008 ENSP00000402842
ENST00000425703
Q5SSR2
Show all »
Show » 194 21.5 No 0
MSH5-010 ENSP00000419648
ENST00000463144
Show » 159 18 No 0
MSH5-011 ENSP00000394971
ENST00000450148
A2ABE9
Show all »
Show » Show » 333 38.1 No 0
MSH5-012 ENSP00000419131
ENST00000497269
43 4.9 No 0
MSH5-017 ENSP00000420232
ENST00000484309
H0YDS7
Show all »
Show » 166 17.9 No 0
MSH5-018 ENSP00000406849
ENST00000429846
A2ABF1
Show all »
Show » 156 16.9 No 0
MSH5-021 ENSP00000406352
ENST00000423982
H7C2J4
Show all »
Show » Show » 637 71.8 No 0
MSH5-201 ENSP00000364894
ENST00000375742
O43196
Show all »
Show » Show » 851 94.7 No 0
MSH5-202 ENSP00000416784
ENST00000431848
B4DZX3
Show all »
Show » Show » 533 59.1 No 0
MSH5-203 ENSP00000431693
ENST00000534153
O43196
Show all »
Show » Show » 851 94.7 No 0