HLA-C

GENERAL INFORMATION

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Gene name

HLA-C

Gene description

Major histocompatibility complex, class I, C

Protein class

Plasma proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

Membrane,Secreted

Number of transcripts

4
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

ANTIBODY RELIABILITY

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Data reliability

Pending normal tissue annotation.
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A


PROTEIN EXPRESSION OVERVIEW

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Pending normal tissue annotation.


RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

HLA-C (HGNC Symbol)

Synonyms

D6S204, HLA-JY3, PSORS1

Description

Major histocompatibility complex, class I, C (HGNC Symbol)

Entrez gene summary

HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described [provided by RefSeq, Jul 2008]

Chromosome

6

Cytoband

p21.33

Chromosome location (bp)

31268749 - 31357158

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000204525 (version 78.38)

Entrez gene

3107

UniProt

P10321 (UniProt - Evidence at protein level)

neXtProt

NX_P10321

Antibodypedia

HLA-C antibodies


PROTEIN BROWSER

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ENST00000376228
 
ENST00000383329
 
ENST00000415537
 
ENST00000620806
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HLA-C-001 ENSP00000365402
ENST00000376228
P10321
Show all »
Show » Show » 366 40.6 Yes 1
HLA-C-002 ENSP00000372819
ENST00000383329
A2AEA2
Show all »
Show » Show » 372 41.3 Yes 1
HLA-C-007 ENSP00000400410
ENST00000415537
B8Y6A8
Show all »
Show » Show » 261 29.4 Yes 0
HLA-C-201 ENSP00000480331
ENST00000620806
B1PQ27
Show all »
Show » Show » 325 36.5 Yes 0