HLA-E

GENE INFORMATION

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Gene name

HLA-E

Synonyms

Description

major histocompatibility complex, class I, E (HGNC Symbol)

Entrez gene summary

HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. [provided by RefSeq, Jul 2008]

Chromosome

6 (Chromosome progress)

Cytoband

p21.33

Chromosome location (bp)

30457244 - 30461982

Ensembl

ENSG00000204592 (version 73.37)

Entrez gene

3133

UniProt

neXtProt

Antibodypedia

HLA-E antibodies
 

PROTEIN VIEW

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HLA-E-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HLA-E-001 ENSP00000365817
ENST00000376630
Q6DU44
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