PSMB10

GENE INFORMATION

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Gene name

PSMB10 (HGNC Symbol)

Synonyms

beta2i, LMP10, MECL1, MGC1665

Description

proteasome (prosome, macropain) subunit, beta type, 10 (HGNC Symbol)

Entrez gene summary

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. Proteolytic processing is required to generate a mature subunit. Expression of this gene is induced by gamma interferon, and this gene product replaces catalytic subunit 2 (proteasome beta 7 subunit) in the immunoproteasome. [provided by RefSeq, Jul 2008]

Chromosome

16 (Chromosome progress)

Cytoband

q22.1

Chromosome location (bp)

67968405 - 67970990

Ensembl

ENSG00000205220 (version 73.37)

Entrez gene

5699

UniProt

P40306 (UniProt - Evidence at protein level)

neXtProt

NX_P40306

Antibodypedia

PSMB10 antibodies
 

PROTEIN VIEW

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PSMB10-001
 
PSMB10-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PSMB10-001 ENSP00000351314
ENST00000358514
P40306
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Show » Show » 273 28.9 No 0
PSMB10-004 ENSP00000463811
ENST00000574576
J3QQN1
Show all »
Show » 138 14.2 No 0