E2F4

GENERAL INFORMATION

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Gene name

E2F4

Gene description

E2F transcription factor 4, p107/p130-binding

Protein class

Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

The majority of normal tissues displayed moderate to strong cytoplasmic and membranous immunoreactivity. Squamous epithelia, testicular cells, myocytes, CNS and lymphoid tissues were negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
CAB016523
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

E2F4 (HGNC Symbol)

Synonyms

E2F-4

Description

E2F transcription factor 4, p107/p130-binding (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer. [provided by RefSeq, Jul 2008]

Chromosome

16

Cytoband

q22.1

Chromosome location (bp)

67192169 - 67198918

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000205250 (version 78.38)

Entrez gene

1874

UniProt

Q16254 (UniProt - Evidence at protein level)

neXtProt

NX_Q16254

Antibodypedia

E2F4 antibodies


PROTEIN BROWSER

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ENST00000379378
 
ENST00000565226
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

E2F4-001 ENSP00000368686
ENST00000379378
Q16254
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Show » Show » 413 44 No 0
E2F4-005 ENSP00000458706
ENST00000565226
Show » 144 14.6 No 0