IPO7

GENE INFORMATION

? »

Gene name

IPO7 (HGNC Symbol)

Synonyms

Imp7, RANBP7

Description

importin 7 (HGNC Symbol)

Entrez gene summary

The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. Similar to importin-beta, this protein prevents the activation of Ran's GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions. At least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins. [provided by RefSeq, Jul 2008]

Chromosome

11 (Chromosome progress)

Cytoband

p15.4

Chromosome location (bp)

9406169 - 9469673

Ensembl

ENSG00000205339 (version 73.37)

Entrez gene

10527

UniProt

O95373 (UniProt - Evidence at protein level)

neXtProt

NX_O95373

Antibodypedia

IPO7 antibodies
 

PROTEIN VIEW

? »
 
 
 
IPO7-001
 
IPO7-002
 
IPO7-003
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IPO7-001 ENSP00000369042
ENST00000379719
O95373
Show all »
Show » Show » 1038 119.5 No 0
IPO7-002 ENSP00000433313
ENST00000533233
E9PLJ0
Show all »
Show » 64 7.1 No 0
IPO7-003 ENSP00000435235
ENST00000527431
E9PLB2
Show all »
Show » 131 15.4 No 0