KRT81

GENE INFORMATION

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Gene name

KRT81 (HGNC Symbol)

Synonyms

Hb-1, KRTHB1

Description

keratin 81 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB3 and KRTHB6, is found primarily in the hair cortex. Mutations in this gene and KRTHB6 have been observed in patients with a rare dominant hair disease, monilethrix. [provided by RefSeq, Jul 2008]

Chromosome

12 (Chromosome progress)

Cytoband

q13.13

Chromosome location (bp)

52679697 - 52685318

Ensembl

ENSG00000205426 (version 73.37)

Entrez gene

3887

UniProt

Q14533 (UniProt - Evidence at protein level)

neXtProt

NX_Q14533

Antibodypedia

KRT81 antibodies
 

PROTEIN VIEW

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KRT81-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

KRT81-001 ENSP00000369349
ENST00000327741
Q14533
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