DENND1B

GENE INFORMATION

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Gene name

DENND1B (HGNC Symbol)

Synonyms

C1orf218, FAM31B, FLJ20054, MGC27044

Description

DENN/MADD domain containing 1B (HGNC Symbol)

Entrez gene summary

Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010]

Chromosome

1 (Chromosome progress)

Cytoband

q31.3

Chromosome location (bp)

197473878 - 197744826

Ensembl

ENSG00000213047 (version 73.37)

Entrez gene

163486

UniProt

Q6P3S1 (UniProt - Evidence at protein level)

neXtProt

NX_Q6P3S1

Antibodypedia

DENND1B antibodies
 

PROTEIN VIEW

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DENND1B-001
 
DENND1B-003
 
DENND1B-004
 
DENND1B-008
 
DENND1B-010
 
DENND1B-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DENND1B-001 ENSP00000375839
ENST00000391979
Q6P3S1
Show all »
Show » 415 45.8 No 0
DENND1B-003 ENSP00000356366
ENST00000367396
Q6P3S1
Show all »
Show » Show » 426 48.3 No 1
DENND1B-004 ENSP00000235453
ENST00000235453
Q6P3S1
Show all »
Show » Show » 396 44.9 No 1
DENND1B-008 ENSP00000294737
ENST00000294737
B3KR95
Show all »
Show » 352 39.8 No 1
DENND1B-010 ENSP00000410025
ENST00000422998
B7ZBL5
Show all »
Show » 147 16.9 No 0
DENND1B-201 ENSP00000383751
ENST00000400967
Q6P3S1
Show all »
Show » Show » 396 44.9 No 1