ATF6B

GENE INFORMATION

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Gene name

ATF6B (HGNC Symbol)

Synonyms

CREBL1, G13

Description

activating transcription factor 6 beta (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

Chromosome

6 (Chromosome progress)

Cytoband

p21.33

Chromosome location (bp)

32065953 - 32096030

Ensembl

ENSG00000213676 (version 73.37)

Entrez gene

1388

UniProt

Q99941 (UniProt - Evidence at protein level)

neXtProt

NX_Q99941

Antibodypedia

ATF6B antibodies
 

PROTEIN VIEW

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ATF6B-001
 
ATF6B-002
 
ATF6B-008
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ATF6B-001 ENSP00000364347
ENST00000375201
Q99941
Show all »
Show » Show » 700 76.4 No 1
ATF6B-002 ENSP00000364349
ENST00000375203
Q99941
Show all »
Show » Show » 703 76.7 No 1
ATF6B-008 ENSP00000393419
ENST00000453203
142 16.1 No 0