ISPD

GENERAL INFORMATION

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Gene name

ISPD

Gene description

Isoprenoid synthase domain containing

Protein class

Disease related genes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Mixed

Protein evidence

Evidence at protein level

Protein localization

Most of the normal cells showed weak to moderate nuclear and/or cytoplasmic staining with additional membranous and extracellular positivity in a few cases. Hepatocytes were strongly stained. Fraction of endometrial glands displayed strong membranous staining. Glial cells, spleen, germinal center cells of lymphoid tissues, hematopoietic cells, smooth and skeletal muscle cells were weakly stained or negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA043810
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Mixed

Organ

Expression



GENE INFORMATION

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Gene name

ISPD (HGNC Symbol)

Synonyms

hCG_1745121, IspD, Nip

Description

Isoprenoid synthase domain containing (HGNC Symbol)

Entrez gene summary

This gene encodes a 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase-like protein. Mutations in this gene are the cause of Walker-Warburg syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2012]

Chromosome

7

Cytoband

p21.2

Chromosome location (bp)

16091192 - 16421322

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000214960 (version 78.38)

Entrez gene

729920

UniProt

A4D126 (UniProt - Evidence at protein level)

neXtProt

NX_A4D126

Antibodypedia

ISPD antibodies


PROTEIN BROWSER

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ENST00000399310
 
ENST00000407010
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ISPD-001 ENSP00000385478
ENST00000407010
A4D126
Show all »
Show » Show » 451 49.9 No 0
ISPD-003 ENSP00000382249
ENST00000399310
A4D126
Show all »
Show » Show » 401 44.4 No 0