DDX3X

GENE INFORMATION

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Gene name

DDX3X (HGNC Symbol)

Synonyms

DBX, DDX14, DDX3, HLP2

Description

DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked (HGNC Symbol)

Entrez gene summary

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which interacts specifically with hepatitis C virus core protein resulting a change in intracellular location. This gene has a homolog located in the nonrecombining region of the Y chromosome. The protein sequence is 91% identical between this gene and the Y-linked homolog. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jul 2010]

Chromosome

X (Chromosome progress)

Cytoband

p11.4

Chromosome location (bp)

41192651 - 41223725

Ensembl

ENSG00000215301 (version 73.37)

Entrez gene

1654

UniProt

O00571 (UniProt - Evidence at protein level)

neXtProt

NX_O00571

Antibodypedia

DDX3X antibodies
 

PROTEIN VIEW

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DDX3X-001
 
DDX3X-201
 
DDX3X-202
 
DDX3X-203
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DDX3X-001 ENSP00000382840
ENST00000399959
O00571
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Show » Show » 662 73.2 No 0
DDX3X-201 ENSP00000414281
ENST00000441189
B4DLA0
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Show » 139 15 No 0
DDX3X-202 ENSP00000392494
ENST00000457138
O00571
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Show » Show » 646 71.4 No 0
DDX3X-203 ENSP00000439799
ENST00000542215
B4E3C4
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Show » 308 33.8 No 0